The Oscar-winning actress said she wanted to have the baby, having just gotten married and ready to start a family.
Sadly, this pregnancy also ended in a miscarriage.
As a result, Jennifer had to get a D&C, the surgical procedure by which tissue is removed from the uterus.
When Jennifer became pregnant again, this time with her now-seven-month-old son Cy, she couldn't stop thinking about the way pregnancy affected her body.
This prompted a whole new perspective on the restrictions women now face over their reproductive rights in the wake of the overturning of Roe v Wade.
"I remember a million times thinking about it while I was pregnant. Thinking about the things that were happening to my body.
"And I had a great pregnancy. I had a very fortunate pregnancy," she said.
"But every single second of my life was different. And it would occur to me sometimes: What if I was forced to do this?"
In the wide-ranging profile, Jennifer also opened up about navigating the difficult conversations around politics with her Republican-voting family back in Kentucky.
“I just worked so hard in the last five years to forgive my dad and my family and try to understand: It’s different. The information they are getting is different. Their life is different,” she said.
The new mum said she can no longer surround herself with people who "aren't political", adding that politics are "killing people".
If you or someone you know has been affected by any of the issues raised in this article, help is always available. You can call the SANDS 24/7 bereavement support line on 1300 308 307 or visit the website.