In an essay for Medium published on Wednesday, Knox wrote: "I’m about to return to Italy for the first time since I was released from prison and fled the country in a high-speed chase, paparazzi literally ramming the back of my stepdad’s rental car."
After Meredith Kercher's body was discovered, Italian Prosecutors alleged that Knox and her then boyfriend, Raffaele Sollecito, had killed Kercher in a twisted sex game gone wrong.
During the murder trial prosecutors painted Knox as a "sex-crazed femme fatale", but Knox's supporters said there was a lack of hard evidence and accused Italian authorities of feeding scandalous stories to the media to make the couple look guilty.
Local man Rudy Guede was also implicated in the murder after his DNA was found both on Meredith Kercher's body and at the crime scene.
Knox and Sollecito spent four years in prison before being acquitted, but were convicted again in absentia in 2013 until another acquittal in 2015.
The international media circus around her trial inspired the 2016 Netflix documentary Amanda Knox.
Knox took to Instagram to reveal she was "feeling frayed" ahead of the trip, posting a bizarre selfie of her hanging off the side of a cliff edge in her home state of Washington.
Feigning fear, she captioned the shot: "3 Days till I return to Italy for the first time since leaving prison. Feeling frayed, so I made my own inspirational workplace poster. "Hang in there!" Just imagine I'm a kitten."
Knox's fiancé Christopher said in a tweet: "Last time I was in Italy, I took a train to Florence, blew my money on a €100 bottle of Barolo which I drank by myself while writing a bad short story. This time with @amandaknox is going to be, shall we say…different.”