The Oscar-winning actress appeared to be on the verge of tears as she spoke to a group of students at Yonsei University - where Maddox will be studying bio-engineering.
Surrounded by students, the mother-of-six was asked how long she would be staying in Seoul.
To this disappointment of her audience, the star replied, "I leave today, today is the day that I drop him off."
As the students groaned at the news, Angie then clutched her chest as though she was about to cry.
"I know, I'm trying not to cry," she said, throwing her hands up.
WATCH: Angelina Jolie 'tries not to cry' when dropping eldest son Maddox off to Yonsei University in South Korea.
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"Yes it's time, thank you very much, it seems like a great school," Angelina continued.
"I'm sure you're all going to like it here."
According to theDaily Mail,Maddox has been learning the Korean language from a tutor.
A college student shared a photo with the Maleficent actress, saying "Thank you miss Jolie for having a 40 seconds conversation with me!"
In a detailed video on YouTube, the student recalled the conversation he had with Angie, revealing that Maddox is studying bioengineering and confirming that he will be living in a dorm room and not off-campus.
The source added that Angelina - who was appointed Special Envoy by UNICEF in 2012 - was kind and Maddox was quiet.
A student at the scene said that Angelina Jolie was kind and Maddox Jolie-Pitt was quiet.