As anticipated, the video is action-packed and fueled with several girl-power moments.
At the start of the clip, the superstar trio appeared to be walking through a grand foyer wearing black angel wings.
In other scenes, Ariana wore white angel wings as she struck glamorous poses around the home.
Lana could be seen walking through a control room at one point and throwing knives at a dartboard during another scene.
Miley was half beating up, half dancing on a man in a boxing ring.
At another point, all three pop stars were seen eating from a dining table of stranger's home.
Watch the music video for "Don't Call Me Angel" featuring Ariana Grande, Miley Cyrus and Lana Del Rey below.
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Fans are already obsessing over the video.
"We can't call Ariana angel because she's already proven that God is a woman and it's HER," one user commented.
However, some were also disappointed that the film clip seemed to mostly show Ariana.
"I love Ariana, but I need a version of this song where Miley and Lana sing a little more," another person said.
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While it is the first time Cyrus and Grande have collaborated with Del Rey, it is the second time they have worked on a duet.
In May 2015, the pair performed a rendition of Crowded House’s "Don’t Dream It’s Over," at Grande’s One Love Manchester benefit concert.
"I’m thrilled that three of my favourite artists ended up doing a song for the film," director Elizabeth Banks - who appeared at the end of the music video - recently told PEOPLE about the single.
Charlie’s Angels, starring Kristen Stewart, Naomi Scott, and Ella Balinska, will be released on November 15.
Sir Patrick Stewart, Jonathan Tucker, Noah Centineo, Sam Claflin and Djimon Hounsou also star.