The divorce papers, obtained by TMZ, also state Forrest is seeking full custody of their three-year-old daughter and spousal support.
The couple married in 2014 at the Chateau Marmont hotel in Hollywood.
Mendelsohn is currently starring in Rogue One: A Star Wars Story.
Rumour has it, he is in talks to play Sheriff of Nottingham in Robin Hood: Origins.
This article originally appeared on New Idea.