During the interview, Depp revealed that he stumbled into acting while trying to pursue music as a teenager.
"I've [been a musician] since I was little – since I was 12 I've played," he said. "I started playing clubs when I was like 13 in Miami."
Depp said he became an actor by "accident."
"I needed to pay rent," said Depp. "Somebody said, 'Why don't you go meet an agent. My agent is with Nick Cage,' so she sent me on an audition for something and I got it."
The actor said it wasn't until his band broke up that he considered acting full-time. "It seemed like a good way to pay the rent for a minute," he said.
Even as his divorce battle with Heard continues, Depp plans to take the stage with his band during their U.S. tour, which kicks off July 1 in Pennsylvania.
A Los Angeles court hearing has been scheduled for Aug. 15 and 16 on Heard's request for a permanent restraining order against Depp amid allegations that he abused her throughout their relationship. A temporary restraining order has been reissued in the interim.
In a response to Heard's allegations, Depp's lawyers claimed in court documents that the actress was "attempting to secure a premature financial resolution by alleging abuse."