Timberlake will be recognised for his constant evolution as an artist over the past 10 years, when the award ceremony airs on July 31.
"From his musical artistry to innovative collaborations," Fox TV’s press release states. "The singer continues to create relevant, chart-topping music, transcending generations of fans.”
Timberlake has won 22 Teen Choice Awards to date – the most by any male - and continues to create chart-topping hits.
His latest, “t Can’t Stop The Feeling”, is nominated in three 2016 Teen Choice categories, including Choice Song from a Movie or TV Show (Trolls), Choice Party Song and Choice Summer Song.
This year also marks 10 years since Timberlake released his critically acclaimed multi-platinum album FutureSex/LoveSounds.