Hosted by Andy Cohen, the whole family will be back to discuss the biggest moments from the era-defining series.
The show debuted in October 2007, making it one of the longest-running reality television series in the US.
It led to a number of spin-off series for the main cast, including Kourtney and Kim Take Miami, Kourtney and Kim Take New York, Khloé and Lamar and Life of Kylie.
It also catapulted the careers of the individual Kardashians and Jenners, who now own multiple successful businesses across the beauty and fashion industries, and have taken on many other endeavours.
The show followed the siblings across many transitional periods of their lives, with marriages, births and divorces covered across the entirety of the show.
Kris Jenner, the matriarch of the Kardashian family, explained that now felt like the ‘right time’ to stop filming the series in an interview with American radio host Ryan Seacrest.
“We’ve had such an amazing run and so grateful for every single moment and everyone we work with,” she said.
Kim Kardashian also spoke about the series ending in an interview with Grazia USA.
WATCH BELOW: The most iconic Keeping Up With The Kardashians moments. Post continues after video...
“Sometimes we just need a break. It’s really simple. We just need a minute to regroup.
“We haven’t had a break for 14 years … we have kids now, and they need us,” she said.