Kim is the first member of the Kardashian-Jenner clan to unfollow either Thompson or Woods and at the time of writing, Khloe still follows both parties.
The move was quickly picked up by Hollywood Unlocked, the same outlet which first reported that the Cleveland Cavaliers basketball player was getting intimate with Kylie's 'wifey' Jordyn at a private party in Los Angeles last weekend.
Despite spending Valentine's Day with Khloe and True - and gifting the girls with an extravagant flower arrangement for the occasion - 27-year-old Tristan was spotted "making out" with 21-year-old Instagram model Jordyn just days later and, per eye witness reports, the pair "couldn't keep their hands off each other".
Jordyn, who has worked as a model and brand ambassador for Khloe's Good American clothing line, is said to have remained in the house with Thompson until 7am the next day.
In a since deleted tweet, Tristan denied rumours branding them "fake news" - but Khloe's best friend Malika Haqq seemingly confirmed reports by commenting "STRONG FACTS" and "these h*es ain't loyal" on separate Instagram posts relating to the incident.
Close Kardashian friend Larsa Pippen also chimed in saying "Amen!!!" while Khloe herself left a suggestive string of shouting head emojis on Hollywood Unlocked's original video.
Hours later, TMZ reported that Rob Kardashian's ex-girlfriend and longtime friend of the sisters' Adrienne Bailon-Houghton had confirmed rumours on her talk show The Real.
"I spoke to somebody who has confirmed to me that it's absolutely true," she said, adding "I think blame should be put on both parties".
This is not the first time fiercely loyal Kim has publicly excommunicated love rat Tristan.
The wife of Kanye West was the first person to unfollow Thompson back in April 2018 when it emerged he had cheated on pregnant Khloe multiple times with multiple women (and continued to do so right up until she went into labour with their first child).
Kardashian fan watchers wait with baited breath for Kylie's reaction to the scandal which comes just one week after Jordyn helped celebrate her daughter Stormi's first birthday with an exotic, sun soaked getaway and an extravagant carnival themed party.
Back in June 2018, the billionaire business mogul revealed Woods lives with her and views her as a second mother to baby Stormi.
The BFFs also recently collaborated on a makeup line for Kylie Cosmetics.
Of her relationship with Kris Jenner's child, Woods previously said: "We're very much the same, but we're also vey different. i think that's what makes us best friends and we are always on the same page about things."
Only time will tell if the inseparable duo remain on the same page about the latest Kardashian scandal.