"It’s irrelevant and I would warn against anybody taking that line as any sort of explanation as to why Meghan sometimes doesn’t get the press she necessarily wants," he told Karl.
Jephson also "strongly advised" Prince Harry against what Karl called "playing the racism card."
"If you take that point of view then you’re going to miss perhaps some more relevant reasons to why Meghan isn’t as popular as she should be," the royal insider said.
Hopkins made it clear that her dislike of Meghan stemmed from that fact that she had harmed Prince Harry’s reputation.
Why do you hate Meghan so much?" Karl asked her. "What has she ever done to you?"
WATCH: Karl Stefanovic's 60 Minutes report on Meghan Markle is slammed
"Oh everything," she responded. "It’s my royal family. This is my country. Prince Harry is my Prince Harry."
Hopkins also referred to Meghan as a hypocrite.
"What does Meghan Markle do? Oh, we’ve got to save the planet. Oh, do one good thing every day. Blah blah blah blah blah. Then what does she do? Get on four private flights to wherever land at 400,000 pounds a week hire and then uses up half the CO2 emissions that anyone else might have had. It’s pure hypocrisy.
"And what is she really? She’s a no one. She’s a divorcee. When did we want a divorcee in the Royal family? She wears bad clothes. When did we ask for that? We’ve just got so much better of our own."