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“It must feel like it would just be kind of like, 'Yeah, we already let that go... why are you here?'"
This isn’t the first time the 27 Dresses star has spoken about her Grey's Anatomy iconic character.
WATCH Katherine Heigl reflect on her iconic character in '27 Dresses'
After her former onscreen husband Alex Karev's (Justin Chambers) marriage to Camilla Luddington's Jo Wilson in Season 14, Heigl told TVLine that she’d "have to start wondering where Izzie is. Like, what is she doing? Where did she go?"
"Alex needed to find love — true love. If she has moved on, then I would expect Izzie to be very happy for him. She would want him to be happy."
