According to Lisa, Karl was the butt of every joke throughout the Logies (which prompted her to check in with him).
"I just wanted to make sure he was OK. He became everybody's favourite punchline that night and that can't be easy," the Aussie TV personality stated.
Lisa's supportive outlook is a far cry from some of her previous comments about the 45-year-old.
She took a not so subtle swipe at Karl after people began speculating that he was gunning for a spot on The Project's panel.
"I think we're all full at the inn at the moment," the Channel 10 journalist told TV Week. "He might have to take a number!"
The two former-Today show hosts were a favourite as far as on-air pairings go - the Sydney Morning Herald reported that their departure from the Today show caused a significant slump in ratings.
Together, the breakfast show hosts reached the most metropolitan ratings weeks in 2016.
Lisa opened up what made their partnership work in her interview with Spectrum.
"Even though Karl and I had an incredibly successful partnership, not even we can specify what it was that worked," Wilkinson says.
"You never know how two people will go until they’re on air and under the spotlight for three-and-a-half hours every day."