The pair decided to talk about Buble's personal experience with the disease. His son Noah received the gut-wrenching diagnosis two years ago - something the entire family are still dealing with.
The 43-year-old choked up talking about his 5-year-old boy, “That was it, man. My whole life ended.”
The Grammy winner was visibly shaken saying, “It’s too hard to talk about, man … basically they said that it wasn’t great. And so we just took it day by day.”
The dad-of-two explained that Noah's illness prompted the entire family to relocate their lives to the Children’s Hospital Los Angeles.
Thankfully Noah has been cured, but the ramifications of his illness has effected the entire family.
“I’m not OK,” he said.
“My wife honestly, when this all started, I became the strength to somehow pull us and lift us and to be positive … and when they got it out, and the chemo was done and they said, ‘We did it, it’s good, he’s OK,’ I just fell.”
Luisana Lopilato and Buble have been married for seven years and together they share Elias, 2, and Vida, 3 months.
“I fell, and my wife picks me up now,” Buble shared.
The singer also spoke about his fluctuating weight admitting, “I don’t care what I look like. I got a beautiful woman who loves me.”