Taking to his Instagram, Sam shared a throwback photo of the siblings smiling alongside each other.
Fans were quick to react, with one Instagram user commenting: "There is so much love and connection in this photo, it is as if in that split second, cancer didn't exist and it was all about a brother literally making his sister giggle <3"
"A beautiful showing pure love and joy. I can see why it would be a favourite for you," another wrote under the candid photo.
"That smile! I adore this photo! I can just imagine the beautiful memories that come with it 💖," one more wrote.
Before she passed, Connie and her actor brother built a legacy together with their charity organisation "Love Your Sister."
Connie lost her battle to breast cancer on September 8, 2017.