Sharing three daughters with wife Blake Lively—James, Inez and Betty—Reynolds also shared that their children definitely keep them on their toes, thanks to their endless energy.
"I'm a parent of three girls. They're wild. I think they have rabies sometimes," he told the audience, leaving us to wonder if they took up after their mother's most famous character, New York's wild child Serena Van Der Woodsen.
Back in March, Reynolds revealed that he's been spending more and more time focusing on his family, rather than his career.
"It's been hell. I'm going right back. I'm taking the first movie I can find," he joked, adding, "No, it's been great. I'm still busy, but I get to be there for my kids in the morning, and at night I get to put everyone to bed, so I love that".
WATCH: Ryan Reynolds films Blake Lively while 'high' in hospital
For Lively, she recently spoke about how her experience with motherhood has left her self-image and how she paves her way in Hollywood with her family in mind.
"I think having children for me made me feel so much more in my skin," Lively told Forbes.
"I never felt more myself or at ease in my own body or more confident—not to say that there aren't a bevy of insecurities coming at me a million times a day, but I just feel incredibly settled."
Naturally, the confidence that her children have helped her achieve trickles down into her personal style and career-focused decision making.
"Family is at the root of everything that I do and it's also at the root of everything that I create," she explained.
"I want to be in films, I want to make films, I want to author films that I would be proud for my children to see. Even the gowns I wear—I just want my kids to be proud."