Lopez stars as Maya, a 40-year-old woman who wishes she "lived in a world where street smarts equals book smarts".
Struggling with frustrations from unfulfilled dreams, her friends create a fake profile for Maya which gives her the opportunity to prove herself in a high-flying Madison Avenue job. What could go wrong?
Directed by Peter Segal, the comedy also stars Leah Remini, Vanessa Hudgens, Treat Williams and Milo Ventimiglia.
Second Act hits in Australia on November 29, 2018.
Check out the trailer below: