He continued, "I’m the father of twins, I have enough sh-- to deal with – literally!"
The 57-year-old, who is married human rights lawyer Amal Clooney, did touch on something dear to his heart - the irresponsible treatment of his friend and new royal Meghan Markle.
"I do want to say, they’re just chasing Meghan Markle everywhere, she’s been pursued and vilified."
He continued, "She’s a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was and its history repeating itself.
"We’ve seen how that ends. I can’t tell you how frustrating that is, just seeing them broadcast a letter from a daughter to a father, she’s getting a raw deal there and I think it’s irresponsible and I’m surprised by that."
For more from our world exclusive interview with George Clooney, keep your eyes peeled for the new issue of WHO!